Fas binding to its ligand, Fas ligand (Fas-L), has been shown to trigger apoptosis 

in various cell types. 

已證明Fas與其配體Fas配體（Fas-L）結合可在各種細胞類型中引發細胞凋亡。

In the present study, we assessed apoptotic activity and examined Fas and Fas-L expression 

in malignant melanomas, Spitz nevi and ordinary melanocytic nevi.

在本研究中，我們評估了凋亡活性並檢測了普通黑素細胞痣中Fas和Fas-L的表達。

In contrast, common nevi demonstrated significant levels of apoptosis 

in the deep parts of the tumor. 

相反，常見的痣在腫瘤的深部表現出顯著的細胞凋亡水平。

In contrast, increased levels of apoptosis in the deep parts of melanocytic nevi 

may reflect and possibly contribute to their benign nature.

相反，黑素細胞痣深部的細胞凋亡水平增加可能反映並可能有助於其良性。

節錄自https://www.ncbi.nlm.nih.gov/pubmed/10082396

由上可知，Fas及TRAIL可以讓和痣有關的黑色素細胞死亡，也可以讓黑色素痣死亡。